Red blood cell substitutes: current status
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چکیده
منابع مشابه
Red blood cell substitutes: current status.
The transfusion of allogeneic blood (or plasma or red cells) involves many hoards (see table 1), some of which may be reduced or avoided. For example, the patient's own blood rather than allogeneic blood may be transfused: by 1990 more than 5% of units collected in the USA were of autologous blood [42]. In the United Kingdom, the National Transfusion Service is now, in some regions at least, pr...
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Two distinct approaches are being explored in red blood cell substitute (RCS) development: hemoglobin-based oxygen carriers (HBOCs) and perfluorocarbon-based oxygen carriers (PFBOCs). HBOCs are based on intra- and/or intermolecularly "engineered" human or animal hemoglobins (Hbs), optimized for O2 delivery and longer intravascular circulation. Some are currently being evaluated in Phase II/III ...
متن کاملHemoglobin-based red blood cell substitutes.
Polyhemoglobin is already well into the final stages of clinical trials in humans with one approved for routine clinical use in South Africa. Conjugated hemoglobin is also in ongoing clinical trials. Meanwhile, recombinant Hb has been modified to modulate the effects of nitric oxide. Other systems contain antioxidant enzymes for those clinical applications that may have potential problems relat...
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Polyhaemoglobins (PolyHb) and perfluorochemicals are in advanced phase III clinical trials and conjugated haemoglobins in phase II clinical trial. New recombinant human haemoglobin with no vasoactivity is being developed. A soluble macromolecule of PolyHb-catalase-superoxide dismutase is being studied as an oxygen carrier with antioxidant properties. New artificial red blood cells that are more...
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CASE #1: 80 year old female with a history of dypsnea on exertion (DOE) and syncope. Workup reveals aortic stenosis (AVA=0.8cm2) and normal coronary arteries by cardiac catheterization with moderate concentric hypertrophy and an EF of 50%. Her other PMH is unremarkable. She was advised by her cardiac surgeon to seek a preoperative anesthetic consultation because she joined the Watch Tower organ...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1995
ISSN: 0007-0912
DOI: 10.1093/bja/74.6.697